منابع مشابه
Genotyping of the UDP-glucuronosyltransferase (UGT) 1A7 gene revisited.
Readers are encouraged to write letters to the editor concerning articles that have been published in GASTROENTEROLOGY. Letters that include original, unpublished data will not be considered. Letters should be typewritten and submitted electronically to In 2001 and in 2003, we published 2 studies reporting the role of single nucleotide polymorphisms (SNPs) of the mu-tagen detoxifying UDP glucur...
متن کاملPredicting Flavonoid UGT Regioselectivity
MACHINE LEARNING WAS APPLIED TO A CHALLENGING AND BIOLOGICALLY SIGNIFICANT PROTEIN CLASSIFICATION PROBLEM: the prediction of avonoid UGT acceptor regioselectivity from primary sequence. Novel indices characterizing graphical models of residues were proposed and found to be widely distributed among existing amino acid indices and to cluster residues appropriately. UGT subsequences biochemically ...
متن کاملUGT bioactivation of AαC
Background: 2-Amino-9H-pyrido[2,3-b]indole (AαC) is a carcinogen formed in tobacco smoke, but little is known about its metabolism in humans. Result: UDP-Glucuronosyltransferases catalyze the binding of N-oxidized-AαC to DNA. Conclusion: Glucuronidation, normally a detoxication pathway, contributes to the genotoxicity of AαC. Significance: The exposure to and UGTbioactivation of AαC provides a ...
متن کاملCost-effectiveness of CYP2B6 genotyping to optimize efavirenz dosing in HIV clinical practice.
AIMS To assess the cost-effectiveness of CYP2B6 genotyping to guide efavirenz dosing for initial HIV therapy in the USA. METHODS We used the Cost-Effectiveness of Preventing AIDS Complications (CEPAC) microsimulation model to project quality-adjusted life expectancy and lifetime costs (2014 US dollars) for efavirenz-based HIV therapy with or without CYP2B6 genotyping. We assumed that with gen...
متن کاملInclusion of CYP3A5 genotyping in a nonparametric population model improves dosing of tacrolimus early after transplantation
Following organ engraftment, initial dosing of tacrolimus is based on recipient weight and adjusted by measured C(0) concentrations. The bioavailability and elimination of tacrolimus are affected by the patients CYP3A5 genotype. Prospective data of the clinical advantage of knowing patient's CYP3A5 genotype prior to transplantation are lacking. A nonparametric population model was developed for...
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ژورنال
عنوان ژورنال: Pharmacological Research
سال: 2016
ISSN: 1043-6618
DOI: 10.1016/j.phrs.2016.01.002